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Case Study Overmethylation and Undermethylation: I hear it a few times a week while working with clients and guiding various doctors. This case study shows how fast methylation can become imbalanced — and how fast it can be rebalanced.
It also shows how sensitive methylation is — and how careful one must be with it. Here is a short case study demonstrating the speed and sensitivity of methylation: Yesterday, I consulted with him for the first time.
His physician prescribed Wellbutrin, Armour Thyroid and Arimidex. Then, his physician prescribed methylfolate without tapering down the medications.
As expected, the methylfolate definitely began working — too well. Here is some of our dialogue via email: Dr Lynch — June 25, 2: I think you are going to have to taper down on your thyroid, Arimidex and Wellbutrin once you begin methylation.
Client — June 26, 2: I stopped the methylfolate and B12 yesterday afternoon and took mg niacin and I feel pretty down and foggy today — and nauseous. Dr Lynch — June 26, 2: Get back on the methylfolate and B12 and stop the niacin — appears you are undermethylated.
Client — June 27, 4: I felt better almost immediately after restarting the methylfolate at mcg. This morning I felt a bit anxious so I took 50 mg niacin and felt calmer within the hour.
What is going on here? This is a classic balancing act between how much methylation is ideal. You can see exactly how fast the balance can shift. First, the client is obviously undermethylated due to his symptoms so his doctor appropriately addressed it through prescribing methylfolate and methylcobalamin.
The only issue is the doctor did not realize how effective methylation is at supporting neurotransmitters and thyroid hormone production.
Then, upon restarting the methylfolate and methylcobalamin, and maintaining his current dosage of medications, he felt great for a few hours. Then anxiety hit due to excessive neurotransmitter production and likely thyroid hormone production.
So — in order to quiet those symptoms, I told him about how niacin works and how to take it and his anxiety decreased almost immediately. Genetics, lifestyle, diet, medications all play a role in how much methylfolate and methylcobalamin are needed — and these amount can change daily as well.
Finding a doctor that understands this is critical — or you will have a difficult time regaining health — and maintaining it. Niacin restored his mood in two ways — at least the two three ways that I am familiar with: SAMe is a major methyl donor.
Thus, when one consumes niacin, SAMe gets used up and methyl donors drop. Thereby excessive methylation goes away. Nicotinic acid also supports the elimination of glutamate. Many with elevated levels of glutamate do not do well with methylfolate or any type of folate until the levels of glutamate are balanced.
Niacin supports the feedback inhibition of the IDO1 gene which feeds into the kyurenine pathway. The niacin slows the loss of tryptophan by pushing it towards serotonin formation.Today we bring back the ever-popular reader case study series with an interesting twist.. First of all, our subject is a new reader, with sizable financial baggage from .
Build Student Confidence Improve Test Performance Promote Our Most Anxious Students Prevalence. The majority of students report being more stressed by tests and by schoolwork than by anything else in their lives.
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A case study of a man in his 30s with social anxiety disorder. Although not highly publicized, social anxiety is the third largest health care issue in the western world.